Protean Pathology Services

• 1978-1983 / MD, University of Naples, First Faculty, Naples, Italy 

• 1987-1988 / Resident, General Surgery, Monmouth Medical Center, Long Branch, MJ 

• 1988-1992 / Resident, Combined Anatomic and Clinical Pathology, Temple University Hospital, Philadelphia, PA 

• 1992-1994  / Fellow in Molecular Pathology, Jefferson Cancer Institute, Thomas  Jefferson University, Philadelphia, PA 

• 1994-1995  / Fellow, Surgical Pathology, University of Pittsburgh Medical Center,     Pittsburgh, PA 

• 1983, Italy, Active

• 2005, Indiana, Inactive #01059993A

• 2006, Florida, Active ME- 00691552006

• 1987 – 1988 / General Surgery, Monmouth Medical Center, Long Branch, NJ 

• 1988 – 1992 / Combined Anatomic and Clinical Pathology, Temple University Hospital, Philadelphia, PA 

• 1995 – 2003 / Member in Residence H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 

• 2003 – 2005 / Medical Director, Physicians Right Path and CytoCor Laboratories 

• 1995 – 2003 / Member of the Gastrointestinal Tumor Program, Moffitt Cancer Center and Research Institute, Tampa, FL 

• 2003 – 2005 / Clinical Associate Professor of Pathology, Department of Pathology, University of South Florida, College of Medicine, Tampa, FL 

• 2005 – 2019 / Member in Residence H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 

• 2005 – 2006 / Interim Chief Anatomic Pathology Division, Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL 

• 2006 – 2008 / Chief Anatomic Pathology Division, Scientific Director Tissue Core, Scientific Co-Director Analytic Microscopy Core, Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, and University of South Florida, College of Medicine, Tampa, FL 

• 2008 – 2011 / Chair Anatomic Pathology Department, Scientific Director Tissue Core and Scientific Co-Director Analytic Microscopy Core Department of Oncologic Sciences, Moffitt Cancer Center, Tampa, FL 

• 2011 – 2019 / Senior Member, Anatomic Pathology Department and Gastrointestinal Tumor Program, Moffitt Cancer Center and Research Institute, Tampa, FL 

• 2019 – 2024 /  Director Pathology Laboratory, Florida Digestive Health Specialists, Lakewood Ranch, Florida 

• 2024 – Present / Independent Contractor, DPCO Consulting, LLC 

1. My publications have mostly focused on markers of tumor progression. This effort included especially studies on the role of IGF1R in tumor proliferation, invasion, metastasis and  apoptosis in colorectal and ovarian cancers; and the studies of the immunogenic phenotype in colon cancer. 

a. Himbert C, Figueiredo JC, Shibata D, Ose J, Lin T, Huang LC, Peoples AR, Scaife CL, Pickron B, Lambert L, Cohan JN, Bronner M, Felder S, Sanchez J, Dessureault S, Coppola D et al. Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study. Differences by Age of Onset. Cancers (Basel). 2021 Jul 29;13(15):3817. doi:10.3390/cancers13153817. PMID: 34359718; PMCID: PMC8345133. 

b. Saller J, Qin D, Felder S, Coppola D. Microsatellite Stable Colorectal Cancer With an Immunogenic Phenotype: Challenges in Diagnosis and Treatment. Clin Colorectal Cancer. 2020 Jun;19(2):123-131. doi: 10.1016/j.clcc.2020.02.003. Epub 2020 Feb 11. PMID: 32171644. 

c. Shahid M, Wang D, Saller J, Ryzhova E, Qin D, Magliocco A, Coppola D. STK11 p.G270W: A Novel Mutation Detected in a Case of MSI High Mixed Medullary-Mucinous Carcinoma of the Transverse Colon. Cancer Genomics Proteomics. 2019 Jul-Aug;16(4):267-272. doi: 10.21873/cgp.20131. PMID: 31243107 

d. Cives M, Strosberg J, Al Diffalha S, Coppola D. Analysis of the immune landscape of small bowel neuroendocrine tumors. Endocr Relat Cancer. 2019 Jan 1;26(1):119-130. doi: 10.1530/ERC-18-0189. PMID: 30400003 

2. I have contributed to the identification of microRNAs and LincRNAs predictors of prognosis and therapy response for a variety of tumor types including breast, colon, ovarian and others. 

a. Chen DT, Hernandez JM, Shibata D, McCarthy SM, Humphries LA, Clark W, Elahi A, Gruidl M, Coppola D, Yeatman T. Complementary Strand MicroRNAs Mediate Acquisition of Metastatic Potential in Colonic Adenocarcinoma. J Gastrointest Surg. 2012: 16(5): 905-12. PMID: 22362069 

b. Donatelli SS, Zhou JM, Gilvary DL, Eksioglu EA, Chen X, Cress WD, Haura EB,Schabath MB, Coppola D, Wei S, Djeu JY. TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells. Proc Natl Acad Sci U S A. 2014 Feb 28. PMCID: PMC3964044 

c. Richards EJ, Zhang G, Li ZP, Permuth-Wey J, Challa S, Li Y, Kong W, Dan S, Bui M, Coppola D (CBMM), Mao WM, Sellers TA, Cheng JQ. Long Non-coding RNAs (LncRNA) Regulated by Transforming Growth Factor (TGF) β: LncRNA-Hit-Mediated Tgfβ- Induced Epithelial to Mesenchymal Transition in Mammary Epithelia. J Biol Chem 2015 Mar; 290: (11) 6857-6867 PMCID: PMC4358111 

3. I described the presence and prognostic role of lymph node-like structures in colon cancer. This finding included the discovery of a chemokine signature capable of predicting tumor prognosis and therapy response not only in colon but also in melanoma and pancreatic cancer, as later demonstrated by other authors. 

a. Coppola D, Mule JJ. Ectopic lymph nodes within human solid tumors. J Clin Oncol. 2008 Sep 20;26(27):4369-70. PMID: 18802146. 

b. Coppola D, Nebrozhyn M, Khalil F, Dai H, Yeatman T, Loboda A, Mule JJ. Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling. Am J Pathol. 2011 Jul;179(1):37-45, PMCID: PMC3123872